The NCDC disclosed this on its official website on Wednesday.
The additional 22 deaths made it the second single-day record for COVID-19 deaths in the country after 23 deaths recorded on January 14.
The Public health agency also announced 1,861 new COVID-19 infections in the last 24 hours in the country.
It added that the country has recorded the 1,861 new cases of COVID-19 making it-the second highest daily new infection in less than one week.
The agency noted that the country has set a new second single-day record for COVID-19 deaths and hospitalisations and has its fourth-highest single-day total of new cases.
The public health agency said that the new infections were reported from 21 states and the Federal Capital Territory.
The NCDC revealed that 773 of the new cases were recorded in Lagos, 285 cases were confirmed in Abuja, the Federal Capital Territory, and Oyo reported 138 cases.
Amongst others states with new cases were: Rivers-111, Plateau-92, Nasarawa-83, Kaduna-59, Enugu-57, Imo-57, Edo-43, Kano-27, Kwara-20, Ebonyi-19, Abia-17, Ogun-12, Osun-12, Katsina-eight, Bayelsa-six, Bauchi-five, Delta-five, Borno-four, Jigawa-four and Zamfara-one.
It noted that the numbers of recoveries and discharged on Wednesday increased by 1,089.
According to the health agency, discharges today include 697 community recoveries in Lagos State, 128 in Rivers State and 116 in Plateau State managed in line with guidelines.